|
|
Publication
|
| Research Title |
Metformin suppresses cholangiocarcinoma cell migration/invasion in association with inhibition of mTOR and FAK pathways |
| Date of Distribution |
27 September 2018 |
| Conference |
| Title of the Conference |
The 77th Annual Meeting of the Japanese Cancer Association |
| Organiser |
The Japanese Cancer Association |
| Conference Place |
Osaka International Convention Center |
| Province/State |
Osaka, JAPAN |
| Conference Date |
27 September 2018 |
| To |
30 September 2018 |
| Proceeding Paper |
| Volume |
2018 |
| Issue |
1 |
| Page |
84 |
| Editors/edition/publisher |
|
| Abstract |
Metformin suppresses cholangiocarcinoma cell migration/invasion in association with inhibition of mTOR and FAK pathways
Jaroon Wandee1, Auemduan Prawan1,2, Laddawan Senggunprai1,2, Sarinya Kongpetch1,2, Veerapol Kukongviriyapa1,2,*
1 Dept. Pharm., Faculty of Med., Khon Kaen Univ., Thailand
2 Cholangiocarcinoma Res. Insti., Khon Kaen Univ, Thailand
*Corresponding author
Cancer metastasis is one of the hallmarks of aggressive cancer which correlates with the poor prognosis of patients. Cholangiocarcinoma (CCA) is an aggressive malignancy with poor prognosis. Metformin (Met), a first-line antidiabetic drug, has been suggested to reduce risk of some cancers. The present study, we found that Met inhibited migration in CCA cells, KKU-100 and KKU-M156, as assessed by wound healing assay. Met also suppressed cell invasion of KKU-452 and KKU-M156 cells by transwell chamber assay. Cisplatin, a standard drug treatment in CCA, used alone or in combination with Met exhibited antiproliferation, but Cis showed modest effects on migration and invasion. The antimigration and antiinvasion effects of Met may be related to the suppression of mTOR and FAK signalings. The role of FAK in migration was affirmed by using PF573228, a selective FAK inhibitor. PF573228 markedly inhibited cell migration in CCA cells similar to Met. These results provide an evidence that Met may be an effective agent for suppression of cancer metastasis. Acknowledgement. This work was supported by grant-in-aid from Faculty of Medicine, Khon Kaen University, Thailand.
|
| Author |
|
| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
true |
| Award Title |
Travel grant |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
The Japanese Cancer Association |
| Date of awarding |
27 กันยายน 2561 |
| Attach file |
|
| Citation |
0
|
|
|
|
|
|
|
|
|
Journal Publication
ไทย