| Research Title |
PLASMA FROM CROCODILE (Crocodylus siamensis) REVEALING ANTIMICROBIAL ACTIVITY AGAINST Pseudomonas aeruginosa |
| Date of Distribution |
1 November 2018 |
| Conference |
| Title of the Conference |
THE 44th CONGRESS ON SCIENCE AND TECHNOLOGY OF THAILAND |
| Organiser |
สมาคมวิทยาศาสตร์แห่งประเทศไทยในพระบรมราชูปถัมภ์ |
| Conference Place |
Bankok International Trad & Exhibition Center (BITEC) |
| Province/State |
Bankok |
| Conference Date |
29 October 2018 |
| To |
31 October 2018 |
| Proceeding Paper |
| Volume |
2018 |
| Issue |
1 |
| Page |
156 |
| Editors/edition/publisher |
|
| Abstract |
Pseudomonas aeruginosa is a biofilm formation type that can cause of drug resistance. Consequently, the discovery of natural molecules which effectively inhibit bacterial cell membrane and also safe therapies is urgently needed. Crocodylus siamensis plasma (C-plasma) has been investigated for their antimicrobial activity. However, the inhibition of biofilm formation bacteria has not been reported. Thus the objectives of this study were to investigate antibacterial activity of C-plasma against P.aeruginosa ATCC 27853 and also observe for their stability under ultraviolet (UV) light. The results from broth micro-dilution assay indicated that C-plasma effectively inhibited P.aeruginosa approximately 2-fold higher than human plasma (H-plasma). Indeed, the efficiency in inhibition the P.aeruginosa growth of C-plasma was averaged by 80%, while the average percentage of inhibition by 40% was obtained in H-plasma. The stability of C-plasma on P.aeruginosa growth inhibition was performed under UVA and UVC treatment. The results showed that C-plasma after treated with UV (1,000 µg/ml) slightly decrease in their percentage inhibition on P.aeruginosa of about 90%, which was a little lower than untreated C-plasma (98%). Hence, the results of this research directly indicated that the strong antimicrobial activity on P.aeruginosa of C-plasma could provide potential candidates for developing therapeutic agents against biofilm formation bacteria. |
| Author |
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
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Publication
Journal Publication
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