| Title of Article |
Serum YKL-40 as a
diagnostic biomarker for cervical squamous cell carcinoma |
| Date of Acceptance |
8 November 2018 |
| Journal |
| Title of Journal |
The Clinical Academia |
| Standard |
OTHER (ASEAN Citation Index (ACI)) |
| Institute of Journal |
Medical Advancement Foundation Khon Kaen Hospital, Muang, Khon Kaen |
| ISBN/ISSN |
|
| Volume |
Volume 42 |
| Issue |
Issue 6 |
| Month |
November-December 2018 |
| Year of Publication |
2018 |
| Page |
|
| Abstract |
Abstarct
AIMS
To assess the diagnostic properties of serum YKL-40 for diagnosis of cervical squamous cell carcinomas (SCC)
METHODS
Blood samples were collected from 56 patients who attended the Obstetrics and Gynecology Clinic at Khon Kaen Hospital in Thailand. YKL-40 levels in serum were detected by enzyme-linked immunosorbent (ELISA) assay in healthy women donors (n=40) and SCC patients (n=56).
RESULTS
Serum YKL-40 was used significantly high in SCC (median: 63.5 ng/ml; range: 23-309 ng/ml) when compared to healthy controls (median: 20.8 ng/ml; range: 3-97 ng/ml). Assessment of serum YKL-40 as a diagnostic marker for SCC using Receiver Operator Characteristic (ROC) curve revealed area under the curve (AUC) of 0.958 (95% confident interval (CI) = 0.916-0.999), the sensitivity of 94.6% and the specificity of 85% with cut-off value of 30.5 ng/ml. The results proved that there isn’t any significant association of low and high serum YKL-40 level with overall survival time in SCC patients who were observed. As a result, patients with high serum YKL-40 level tended to have poor prognosis compared to those with low serum YKL-40.
CONCLUSION
The study indicates that serum YKL-40 can be used as a diagnostic marker for SCC with high sensitivity and specificity.
|
| Keyword |
Cervical cancer, YKL-40, ELISA |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
|
| Citation |
0
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Publication
Journal Publication
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