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Publication
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| Title of Article |
Antitumor effects of flavopiridol, a cyclin-dependent kinase inhibitor, on human cholangiocarcinoma in vitro and in vivo xenograft model |
| Date of Acceptance |
3 May 2019 |
| Journal |
| Title of Journal |
Heliyon |
| Standard |
SCOPUS |
| Institute of Journal |
Elsevier BV |
| ISBN/ISSN |
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| Volume |
2019 |
| Issue |
5 |
| Month |
พฤษภาคม |
| Year of Publication |
2019 |
| Page |
https://doi.org/10.1016/j.heliyon.2019.e01675 |
| Abstract |
Flavopiridol, a pan-cyclin-dependent kinase (CDK) inhibitor, was recently identified as an effective antitumor agent for several cancers. We investigated the antitumor effect of flavopiridol on cholangiocarcinoma (CCA), in vitro and in vivo. A methylthiotetrazole assay revealed that the proliferation of certain CCA cells was inhibited by flavopiridol, which induced the caspase-dependent apoptosis of CCA cells. Although increased cell cycle arrest was observed at the G2/M phase, caspase activation occurred earlier than 24 h, indicating that caspase-dependent apoptosis is the major pathway for the suppression of cell proliferation. Flavopiridol potently reduced the CCA tumor growth in a xenograft model without observable adverse effects. These findings indicated that flavopiridol could be a potential antitumor agent for the treatment of CCA. |
| Keyword |
Biochemistry, Cancer research, Molecular biology |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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