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Publication
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| Research Title |
Gut microbiome and metabolic profiling of opisthorchiasis hamster reveal the possible biomarkers for cholangiocarcinoma |
| Date of Distribution |
26 September 2019 |
| Conference |
| Title of the Conference |
The 78th Annual Meeting of Japanese Cancer Association |
| Organiser |
Laboratory of Cell Cycle Regulation, Graduate School of Biostudies, Kyoto University |
| Conference Place |
Kyoto International Conference Center, Takaragaike, Sakyo-ku, Kyoto 606-0001, Japan |
| Province/State |
Kyoto, Japan |
| Conference Date |
26 September 2019 |
| To |
28 September 2019 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
- |
| Editors/edition/publisher |
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| Abstract |
Opisthorchis viverrini (Ov) infection is important risk factor for Cholangiocarcinoma (CCA). Gut dysbiosis and changes of metabolite have been involved in development of many diseases. However, the consequences of O. viverrini infection and liver metabolites have never been explore. Here we aimed to investigate the effect of O. viverrini infection on gut microbiome and metabolite in opisthorchiasis hamsters. 1H NMR spectroscopy revealed that metabolites in liver extracts of opisthorchiasis hamster were deviated from controls. Theses alteration were found along with the decreases of faecal microbial diversity, Firmicutes to Bacteroidetes ratio and abundance of Lactobacillus, Faecalibaculum and Bifidobacterium. In the other hand, the abundance of Methanobrevibacter and Akkermansia were increased. In conclusion, O. viverrini infection induces the changes in gut microbiome and liver metabolism and these changes correlate with hepatobiliary pathology and hence, might be applied for development of screening as well as prevention approaches for opisthorchiasis and CCA. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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