| Research Title |
Localization of muscarinic receptor M1 in three major salivary glands of adult mice in immuno-light and electron microscopy |
| Date of Distribution |
24 May 2018 |
| Conference |
| Title of the Conference |
การประชุมกายวิภาคศาสตร์แห่งประเทศไทยครั้งที่ 41 |
| Organiser |
สมาคมกายวิภาคศาสตร์แห่งประเทศไทย |
| Conference Place |
โรงแรมดุสิตธานี หัวหิน-ชะอำ จังหวัดเพรชบุรี |
| Province/State |
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| Conference Date |
23 May 2018 |
| To |
25 May 2018 |
| Proceeding Paper |
| Volume |
62 |
| Issue |
3 |
| Page |
403-406 |
| Editors/edition/publisher |
|
| Abstract |
Abstract
Background : The regulation of saliva secretion is crucial for oral homeostasis and it is maintained under the autonomic nervous function. The cholinergic regulation of salivation is initiated by muscarinic receptors M1 and M3 with the latter being a major contributor. In view of the general idea that a minor of the two contributors in a given function exerts a crucial modulatory role.
Objective : The present study was attempted to localize the M1 in three major salivary glands of adult mice.
Methods : Three major salivary glands of male adult mice were utilized for immuno-light and electron microscopic analyses.
Results : M1-immunoreactivity was seen in the cytoplasm of all ductal cells, but not in acini. In parotid gland ducts, the immunoreactivity was variable in intensity in different cells along their trajectory. Some moderately immunoreactive cells might show their individual cell contour distinctly because the immunoreactivity was denser along the apical and lateral plasmalemma. In submandibular granular convoluted tubules, the immunoreactivity was weak along the basal plasmalemma. In sublingual striated ducts, the immunoreactivity was diffusely weak throughout the cytoplasm. In intercalated ducts of submandibular and sublingual glands, though short in the latter, some epithelial cells were often present exhibiting moderate immunoreactivity throughout the cytoplasm. Such cells were infrequently found in parotid intercalated ducts.
Conclusions : The present findings suggest that pharmacologically reported heterogeneous Ca2+mobilization in response to muscarinic receptor-agonists may be ascribed to the heterogeneity in the distribution of M1-immunoreactivity in glandular cells and on their plasma membranes along the longitudinal trajectory of the secretory tubular system.
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| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย