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Publication
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| Title of Article |
Thalassemia and hemoglobinopathies in an ethnic minority group in northern Vietnam |
| Date of Acceptance |
6 September 2019 |
| Journal |
| Title of Journal |
Hemoglobin (IHEM) |
| Standard |
SCOPUS |
| Institute of Journal |
Taylor & Francis |
| ISBN/ISSN |
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| Volume |
43 |
| Issue |
03 oct 2019 |
| Month |
October |
| Year of Publication |
2019 |
| Page |
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| Abstract |
This study assessed thalassemia and hemoglobinopathies in a group of the Tay ethnic minority. Participants included 289 women of reproductive-age who enrolled in a pilot screening program for thalassemia conducted at six communities of Thai Nguyen Province, northern Vietnam. Standard proce- dures including complete blood count (CBC), hemoglobin (Hb) and DNA analyses were performed for all samples. The prevalence of thalassemia in 289 Tay women was 15.6% (gene frequency 0.078) for a0-thalassemia (a0-thal), 10.0% (gene frequency 0.050) for aþ-thal, 7.3% (gene frequency 0.036) for b-thalassemia (b-thal), 2.4% (gene frequency 0.012) for Hb Constant Spring [Hb CS; a142, Term!Gln, TAA>CAA (a2), HBA2: c.427T>C] and 1.7% (gene frequency 0.009) for Hb E [b26(B8)Glu!Lys, GAG>AAG; HBB: c.79G>A]. Further analysis of b-globin gene abnormalities identified four mutations including codons 41/42 (–TCTT) (HBB: c.126_129delCTTT), codon 17 (A>T) (HBB: c.52A>T), codons 71/72 (þA) (HBB: c.216_217insA), and –28 (A>G) (HBB: c.78A>G). The results hint at the remarkably high frequencies of severe forms of thalassemia that indicate a serious public health problem requiring further exploration, and most probably, also intervention within the country. |
| Keyword |
Thalassemia, hemoglobinopathy, ethnic minority, tay people, vietnam |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย