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Publication
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| Title of Article |
Whole Grain Essential Oil Reduces Blood Pressure by Increasing Nitric Oxide Level and Alleviating Oxidative Stress in Nitric Oxide Deficient Hypertensive Rats |
| Date of Acceptance |
12 September 2019 |
| Journal |
| Title of Journal |
ศรีนครินทร์เวชสาร |
| Standard |
TCI |
| Institute of Journal |
ฝ่ายวิชาการ คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น |
| ISBN/ISSN |
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| Volume |
34 |
| Issue |
6 |
| Month |
พฤศจิกายน-ธันวาคม |
| Year of Publication |
2019 |
| Page |
614-619 |
| Abstract |
Background and objective: Excessive oxidative stress is associated with the development of hypertension. Consumption of dietary antioxidants appears to decrease blood pressure, preserve endothelial function and reduce the risk for CVD. Whole grain essential oil (WEO) possesses the strong antioxidant property and has been reported to reduce the CVD risk. A rat model of hypertension induced by N𝝎-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase (NOS) inhibitor, is wildly used to study hypertension. Therefore, the present study aims to evaluate the antihypertensive effect of WEO in nitric oxide deficient hypertensive rats.
Methods: Hypertension was induced in male Sprague-Dawley rats by administration of L-NAME (50 mg/kg/day) in their drinking water for 3 weeks. WEO at doses of 1 and 2 ml/kg/day were intragastrically administered during L-NAME administration. Rats received tap water and administered with deionized water were served as normotensive controls.
Results: A markedly increased arterial blood pressure, increased hindlimb vascular resistance and decreased hindlimb blood flow was found in L-NAME-treated rats (p < 0.05). Increase in oxidative stress markers and decrease in nitric oxide (NO) metabolites were also found in L-NAME hypertensive rats (p < 0.05). WEO supplementation significantly attenuated the hemodynamic changes, decreased oxidative stress and restored NO level in L-NAME hypertensive rats (p < 0.05).
Conclusions: WEO supplementation can protect against developing high blood pressure. These effects may be due to its antioxidant activities and the ability to restore NO bioavailability. Results of this study indicate that WEO may be used in dietary applications with a potential to attenuate oxidative stress and reduce cardiovascular risk factors like hypertension.
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| Keyword |
Whole grain essential oil, Hypertension, L-NAME, Nitric oxide, Oxidative stress |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
ชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
5
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Journal Publication
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