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Publication
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| Title of Article |
Evaluation of antifungal effect and toxicity of xanthyletin and two bacterial metabolites against Thai
isolates of Pythium insidiosum |
| Date of Acceptance |
19 February 2020 |
| Journal |
| Title of Journal |
Scientific Reports |
| Standard |
SCOPUS |
| Institute of Journal |
Springer Nature Limited |
| ISBN/ISSN |
2045-2322 |
| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2020 |
| Page |
10 |
| Abstract |
Pythiosis is a harmful disease caused by Pythium insidiosum, an aquatic oomycete. Therapeutic protocols based on antifungal drugs are often ineffective because the cytoplasmic membrane of
P. insidiosum does not contain ergosterol. Therefore, the treatment of pythiosis is still challenging, particularly making use of natural products and secondary metabolites from bacteria. In this study, xanthyletin and substances obtained from Pseudomonas stutzeri ST1302 and Klebsiella pneumoniae ST2501 exhibited anti-P. insidiosum activity and, moreover, xanthyletin was non-toxic against human cell lines. The hyphae of P. insidiosum treated with these three substances exhibited lysis holes on
a rough surface and release of anamorphic material. Therefore, xanthyletin could be considered a promising alternative agent for treating cutaneous pythiosis in the near future. |
| Keyword |
Pythium insidiosum, Pseudomonas stutzeri, Klebsiella pneumoniae, xanthyletin, scanning electron microscopy, cytotoxicity |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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