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Publication
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| Title of Article |
Memory Enhancing Effect of Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in Animal Model of Ischemic Stroke with Metabolic Syndrome |
| Date of Acceptance |
26 June 2020 |
| Journal |
| Title of Journal |
Oxidative medicine and cellular longevity |
| Standard |
ISI |
| Institute of Journal |
Hindawi Publishing Corporation |
| ISBN/ISSN |
1942-0994 |
| Volume |
2020 |
| Issue |
2020 |
| Month |
July |
| Year of Publication |
2020 |
| Page |
19 pages |
| Abstract |
The prevalence of dementia following cerebral ischemia in metabolic syndrome (MetS) condition is increasing and the severity is often severe. Unfortunately, no effective strategy for treating this condition is available. Based on the positive modulation effect of the polyphenol rich substance on dementia, the improvement in bioavailability and stability of polyphenol induced by phytosome technique together with the synergistic concept, we hypothesized that phytosome containing the combined extract of mulberry fruit and ginger (PMG) should mitigate dementia and memory impairment following ischemic stroke in MetS. Male Wistar rats, weighing 180-200 g, were induced MetS by exposing to a 16-week feeding period of high carbohydrate high fat (HCHF) diet. MetS rats were orally given PMG at doses of 50, 100 and 200 mg.kg-1 BW 21 days before and 21 days after the occlusion of right middle cerebral artery (Rt. MCAO). Then, they were determined spatial memory and explored the possible underlying mechanisms via the alterations of acetylcholinesterase (AChE), neuron density, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), interleukin-6 (IL-6) and signal transduction via extracellular signal-regulated kinase (ERK) pathway in both cerebral cortex and hippocampus. It was found that PMG significantly enhanced memory. It also decreased AChE, IL-6 and MDA but increased SOD, CAT, GSH-Px, neuron density and phosphorylation of ERK. These data suggested the cognitive enhancing effect of PMG. The possible underlying mechanisms might occur partly via the improvement of cholinergic function via ERK pathway together with the decrease in neurodegeneration induced by the reduction of oxidative stress and inflammation. However, subchronic toxicity study is also required to consumption safety of PMG before moving forwards to clinical trial study. |
| Keyword |
Dementia, Ginger, Metabolic syndrome, Mulberry fruit, Stroke |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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