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Publication
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| Title of Article |
Effects of oral vitamin C treatment on metabolism at rest and in response to an acute exercise in patients with poorly controlled
type 2 diabetes mellitus |
| Date of Acceptance |
29 March 2020 |
| Journal |
| Title of Journal |
Archives of Allied Health Sciences |
| Standard |
TCI |
| Institute of Journal |
,มหาวิทยาลัยขอนแก่น |
| ISBN/ISSN |
730-1990 |
| Volume |
2020 |
| Issue |
32 |
| Month |
may-august |
| Year of Publication |
2020 |
| Page |
36-50 |
| Abstract |
Metabolic disturbances at rest and in responses to exercise are the hallmarks of type 2 diabetes mellitus (T2DM). Although vitamin C was shown to
improve resting glycemia and lipid profile in patients with T2DM, a study
investigating the effects of vitamin C treatment on the metabolic responses
at rest and to low-intensity exercise in poorly controlled T2DM patients has not been conducted yet. This study aimed to investigate the effects of
oral vitamin C treatment on metabolism at rest and in response to an acute exercise in patients. Twenty T2DM patients randomly participated in the
following two six-week arms with a six-week washout period: either daily placebo or 1000 mg vitamin C. On the first and last day of each session, they performed 20-min low-intensity cycling. Five-min expired gas was collected before starting and finishing the exercise. Immediately before and after the exercise, venous blood samples were collected. Vitamin C decreased resting cholesterol concentration compared with placebo treatment (p-value < 0.05) without any effect after the exercise. Post-vitamin C
treatment, fat oxidation rate was higher during exercise than baseline (p-value < 0.05). Resting total cholesterol/high-density lipoprotein-cholesterol and glucose concentrations in plasma at rest and after exercise were lower at post- compared with pre-vitamin C treatment (p-value <0.05). Additionally, pre- and post-treatment, rates of oxygen consumption and carbohydrate
oxidation, and energy expenditure were higher during exercise than baseline in both treatment arms (p-value <0.05). The findings suggest
that daily treatment with 1000 mg of vitamin C for six weeks reduced the resting cholesterol concentration in patients with poorly glycemic
controlled T2DM. However, this effect was not observed immediately after exercise. Nonetheless, post-vitamin C treatment, fat utilization during exercise was higher than baseline. Besides, low-intensity exercise increased oxygen consumption rate, carbohydrate oxidation rate, and energy expenditure, pre- and post- both treatment arms. |
| Keyword |
Ascorbic acid;Hyperglycemia;Insulin resistance;Lipid oxidation;Physical activity |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
ชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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