| Title of Article |
High Monopolar Spindle 1 Is Associated with Short Survival of
Cholangiocarcinoma Patients and Enhances the Progression Via
AKT and STAT3 Signaling Pathways |
| Date of Acceptance |
9 January 2021 |
| Journal |
| Title of Journal |
biomedicines |
| Standard |
ISI |
| Institute of Journal |
Multidisciplinary Digital Publishing Institute |
| ISBN/ISSN |
|
| Volume |
2021 |
| Issue |
9 |
| Month |
January |
| Year of Publication |
2021 |
| Page |
68 |
| Abstract |
Cholangiocarcinoma (CCA) is a malignancy of the bile duct epithelium. The major problems
of this cancer are late diagnosis and a high rate of metastasis. CCA patients in advanced stages
have poor survival and cannot be cured with surgery. Therefore, targeting molecules involved in the
metastatic process may be an effective CCA treatment. Monopolar spindle 1 (MPS1) is a kinase protein
that controls the spindle assemble checkpoint in mitosis. It is overexpressed in proliferating cells and
various cancers. The functional roles of MPS1 in CCA progression have not been investigated. The
aims of this study were to examine the roles and molecular mechanisms of MPS1 in CCA progression.
Immunohistochemistry results showed that MPS1 was up-regulated in carcinogenesis of CCA in
a hamster model, and positive expression of MPS1 in human CCA tissues was correlated to short
survival of CCA patients (n = 185). Small interfering RNA (siRNA)-induced knockdown of MPS1
expression reduced cell proliferation via G2/M arrest, colony formation, migration, and invasion.
Moreover, MPS1 controlled epithelial to mesenchymal transition (EMT)-mediated migration via
AKT and STAT3 signaling transductions. MPS1 was also involved in MMPs-dependent invasion of
CCA cell lines. The current research highlights for the first time that MPS1 has an essential role in
promoting the progression of CCA via AKT and STAT3 signaling pathways and could be an attractive
target for metastatic CCA treatment. |
| Keyword |
MPS1; Cholangiocarcinoma; migration; invasion; AKT; STAT3; EMT; MMPs |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
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