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Publication
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| Title of Article |
Genetic Polymorphisms of Drug-Metabolizing
Enzymes Involved in 6-Mercaptopurine-Induced
Myelosuppression in Thai Pediatric Acute
Lymphoblastic Leukemia Patients |
| Date of Acceptance |
10 June 2020 |
| Journal |
| Title of Journal |
Journal of Pediatric Genetics |
| Standard |
SCOPUS |
| Institute of Journal |
Georg Thieme Verlag KG |
| ISBN/ISSN |
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| Volume |
2021 |
| Issue |
10 |
| Month |
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| Year of Publication |
2022 |
| Page |
29-34 |
| Abstract |
Genetic polymorphisms of thiopurine S-methyltransferase (TPMT) and nucleoside
diphosphate-linked moiety X-type motif 15 (NUDT15) genes have been proposed as
key determinants of 6-mercaptopurine (6-MP)-induced myelosuppression in pediatric
acute lymphoblastic leukemia (ALL). In the present study, genotypes of TPMT and
NUDT15 were investigated in 178 Thai pediatric patients with ALL by the TaqMan SNP
genotyping assay and DNA sequencing. The frequency of TPMT3C was 0.034. Among
NUDT15 variants, NUDT153 is the most common variant with the allele frequency of
0.073, whereas those of NUDT152, NUDT155, and NUDT156 variants were 0.022,
0.011, and 0.039. These data suggest that a high proportion of Thai pediatric ALL
patients may be at risk of thiopurine-induced myelosuppression. |
| Keyword |
thiopurine methyltransferase, nucleoside diphosphate-linked moiety X-type motif 15, pediatric acute lymphoblastic leukemia |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย