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Publication
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| Title of Article |
Apoptosis-Inducing Factor,
Mitochondrion-Associated 3 (AIFM3)
Protein Level in the Sera as a Prognostic
Marker of Cholangiocarcinoma Patients |
| Date of Acceptance |
7 July 2020 |
| Journal |
| Title of Journal |
Biomolecules |
| Standard |
ISI |
| Institute of Journal |
MDPI publisher |
| ISBN/ISSN |
2218-273X |
| Volume |
2020 |
| Issue |
10 |
| Month |
July |
| Year of Publication |
2022 |
| Page |
1021 |
| Abstract |
Prognosis of cholangiocarcinoma (CCA) patients is absolutely poor. Since improvement
of prognosis and/or response to treatment by personalized and precision treatments requires
earlier and precise diagnostic markers, discovery of prognostic markers attracts more attention.
Apoptosis-inducing factor, mitochondrion-associated 3 (AIFM3) is highly expressed in several cancers
including CCA. The present study investigated whether the serum AIFM3 level can be used as
a potential marker for CCA prognosis. For this purpose, we first determined secretory protein nature
of AIFM3 using bioinformatic tools. The results show that although AIFM3 lacks signal peptide, it can
be secreted into plasma/serum via an unconventional pathway. Then, the AIFM3 levels in the sera of
141 CCA patients and 70 healthy controls (HC) were measured using a semi-quantitative dot blot assay.
The results show that the AIFM3 level in the sera of CCA group was significantly higher than that of
HC. When correlation between serum AIFM3 levels and the clinicopathological parameters of CCA
patients were examined, serum AIFM3 levels correlated significantly with lymph node metastasis,
age, and the patients’ overall survival (OS). Higher AIFM3 levels were significantly associated with
shorter OS, and only AIFM3 was an independent prognostic marker for CCA. In conclusion, AIFM3
can be used as a prognostic marker for CCA. |
| Keyword |
AIFM3; serum; dot blot; prognostic marker; CCA |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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