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Publication
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| Title of Article |
Metabolic phenotyping predicts gemcitabine and cisplatin chemosensitivity in cholangiocarcinoma patients |
| Date of Acceptance |
3 January 2022 |
| Journal |
| Title of Journal |
frontiers in Public Health |
| Standard |
SCOPUS |
| Institute of Journal |
Frontiers |
| ISBN/ISSN |
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| Volume |
2022 |
| Issue |
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| Month |
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| Year of Publication |
2022 |
| Page |
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| Abstract |
Gemcitabine and cisplatin serve as appropriate treatments for cholangiocarcinoma (CCA) patients. Our previous study using histoculture drug response assay (HDRA), demonstrated individual response patterns to gemcitabine and cisplatin. The current study aimed to identify predictive biomarkers for gemcitabine and cisplatin sensitivity in tissues and sera from CCA patients using metabolomics. Metabolic signatures of CCA patients were correlated with their HDRA response patterns. The tissue metabolic signatures of CCA patients revealed the inversion of the TCA cycle that is evident with increased levels of citrate and amino acid backbones as TCA cycle intermediates, and glucose which corresponds to cancer stem cell properties. The protein expression levels of cancer stem cell markers were examined on tissues and showed the significantly inverse association with the patients’ responses to cisplatin. Moreover, the elevation of ethanol level was also observed in gemcitabine- and cisplatin-sensitive group. In serum, a lower level of glucose but a higher level of methylguanidine were observed in the gemcitabine-responders as non-invasive predictive biomarker for gemcitabine sensitivity. Collectively, our findings indicate that these metabolites may serve as the predictive biomarkers in clinical practice which not only for predict chemotherapy response in CCA patients but also minimize the adverse effect from chemotherapy. |
| Keyword |
Cholangiocarcinoma (CCA), gemcitabine, cisplatin, nuclear magnetic resonance spectroscopy (NMR), predictive biomarker and metabolomics |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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