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Publication
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| Title of Article |
13-cis-retinoic acid inhibits proliferation, metastasis and reverses EMT in cholangiocarcinoma cells |
| Date of Acceptance |
19 December 2022 |
| Journal |
| Title of Journal |
International Journal of Molecular Medicine |
| Standard |
ISI |
| Institute of Journal |
Spandidos Publications |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2022 |
| Page |
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| Abstract |
13-cis-Retinoic acid (13CRA), a Food and Drug Administration-approved drug for severe acne, is currently being investigated for its potential use in skin cancer prevention. 13CRA has been reported to exhibit antitumor activity against various types of cancer cells both in vitro and in vivo. However, no information is available regarding the effects of 13CRA on cholangiocarcinoma (CCA), a malignancy of bile duct epithelia. Currently, there are no reliably effective therapeutic options for metastatic CCA. The present study aimed to evaluate the effects of 13CRA on the self-renewal, migration, invasion and adhesion activities of CCA cells, and also investigated the underlying mechanism of its actions. The results showed that 13CRA suppressed cell proliferation via inhibition of self-renewal in CCA cells. 13CRA induced cell cycle arrest at the G2/M phase in KKU-100 and KKU-213B CCA cells through the regulation of cell cycle-regulatory genes and proteins. 13CRA reduced the cell migration ability of both cell lines via modulation of the genes and proteins associated with epithelial-mesenchymal transition. 13CRA also inhibited the invasion and adhesion capabilities of CCA cells via suppression of genes and proteins associated with invasion and adhesion in CCA cells. The results suggested that 13CRA had suppressive roles in CCA cell proliferation, migration, adhesion and invasion |
| Keyword |
13-cis-retinoic acid, cholangiocarcinoma, proliferation, migration, invasion, epithelial-mesenchymal transition |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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