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Publication
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| Title of Article |
TLR4, BTN1A1, and Pit-1 polymorphisms and their associations with the estimated breeding values of growth traits of Brahman cattle in Thailand |
| Date of Acceptance |
19 June 2023 |
| Journal |
| Title of Journal |
Asia-Pacific Journal of Science and Technology (APST) |
| Standard |
SCOPUS |
| Institute of Journal |
Khon Kaen University,Research and Technology Transfer Affairs Division |
| ISBN/ISSN |
2539-6293 |
| Volume |
29 |
| Issue |
1 |
| Month |
january |
| Year of Publication |
2024 |
| Page |
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| Abstract |
The molecular analysis of genes is considered an acceptable tool for accelerating the genetic improvement of production performance in cattle. Single nucleotide polymorphisms (SNPs) in Toll-like receptor 4 (TLR4) and Butyrophilin subfamily 1 member A1 (BTN1A1) genes are related to immunity and may affect all aspects of cattle production. Pituitary-specific positive transcription factor 1 (Pit-1) is related to expression of the growth hormone-releasing factor gene. There were used in this study to examine the associations with estimated breeding values (EBVs) of growth traits [birth weight (BW), weaning weight (WW), and yearling weight (YW)] of Brahman cattle. Two hundred sixty-five cattle blood samples were obtained for DNA extraction, and gene polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The TLR4 gene was associated with the EBV of WW, which was significantly higher with the AB genotype than with the AA genotype (p≤0.05) in cattle. This gene was associated with the EBV of YW, which was significantly higher in the cattle with the AB genotype than in those with the AA genotype (p≤0.05). Cattle with the genotypes AA and AB had a higher (p≤0.05) EBV of WW than cattle with the BB genotype of the BTN1A1 gene, which was also significant. The Pit-1 gene was associated with the EBV of BW, which was significantly lower in cattle with the genotype BB than in those with the genotype AA (p≤0.05). The possibility of selecting for growth traits using these three genetic markers is therefore interesting.
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| Keyword |
Thai Brahman cattle, TLR4, BTN1A1, Pit-1, Growth traits, EBV |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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