| Research Title |
Dextran Sulfate Sodium Induced Ulcerative Colitis in Mice
via Oxidative Stress Pathway
|
| Date of Distribution |
16 April 2019 |
| Conference |
| Title of the Conference |
The 11th Annual Conference of Northeast Pharmacy Research 2019 |
| Organiser |
คณะเภสัชศาสตร์ มหาวิทยาลัยมหาสารคาม |
| Conference Place |
คณะเภสัชศาสตร์ มหาวิทยาลัยมหาสารคาม |
| Province/State |
มหาสารคาม |
| Conference Date |
16 March 2019 |
| To |
17 March 2019 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
73 |
| Editors/edition/publisher |
|
| Abstract |
Introduction: The oxidant/antioxidant balance is suggested to be one of a significant factor for progression and recurrences of ulcerative colitis (UC). The present study aimed to investigate dextran sulfate sodium (DSS)-induced UC in mice via oxidative stress pathway. Materials and methods: UC was induced in adult male ICR mice by daily oral administration of DSS (40 kDa) solution (6 g/kg/day) using gastric lavage for 4 and 7 days (n=4). The control mice were simply given drinking water (1 mL/day). After the end of induction, colon was collected to determine expressions of superoxide dismutase 1 (Sod1), superoxide dismutase 2 (Sod2), and catalase (Cat) mRNA by RT-qPCR. Results: DSS significantly suppressed the expression levels of Sod1 and Sod2 mRNA compared to the control at both day 4 and day 7 of the induction. The expression of Cat mRNA was significantly down-regulated in DSS-treated mice on the day 7 compared to the control. Conclusion: These findings assured the pro-oxidant potential of DSS to induce UC in ICR mice by decreased mRNA expression of Sod1, Sod2, and Cat. It is of interest for further study that DSS-induced colitis in ICR mice on oxidative/antioxidant balance.
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| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย