2012 ©
             TH, publication_detail
TH, publication_article
TH, publication_article_article_name Oral administration of melatonin or succinyl melatonin niosome gel benefits 5-FUinduced small intestinal mucositis treatment in mice 
TH, publication_article_accepted_date 20 January 2021 
TH, publication_article_journal
     TH, publication_article_journal_name AAPS PharmSciTech 
     TH, publication_article_journal_standard ISI 
     TH, publication_article_institute springer 
     TH, publication_article_isbn 1530-9932 
     TH, publication_article_year 2021 
     TH, publication_article_issue
     TH, publication_article_month -
     TH, publication_article_print_year 2021 
     TH, publication_article_page
     TH, publication_article_abstract Mucositis is one of the most adverse effects of 5-fluorouracil (5-FU) and had no standard drug for treatment. Melatonin is a neurohormone, can ameliorate radiotherapy-induced small intestinal mucositis. Melatonin encapsulated in niosomes improved its poor bioavailability. Succinyl melatonin, a melatonin derivative, showed prolonged release compared with melatonin. This study investigated the efficacy of melatonin niosome gel (MNG) and succinyl melatonin niosome gel (SNG) in 5-FU-induced small intestinal mucositis treatment in mice. MNG and SNG with particle sizes of 293 and 270 nm were shown to have mucoadhesive potentials. The effect of a daily oral application of MNG, SNG, or fluocinolone acetonide gel (FAG, positive control) was compared to that of the normal group. The body weight, food consumption, histology, Fourier transform infrared (FTIR) spectroscopy, inflammatory cytokines (tumor necrosis factor (TNF)-α and interleukin (IL)- 1β), and malondialdehyde (MDA) in the small intestine were monitored. The results showed decreased %body weight and food consumption in all 5-FU-injected groups compared with the normal group. The MNG and SNG treatments maintained the food consumption and the normal integrity of the small intestines, as evidenced by villus length and crypt depth, similar to the observations in the normal groups. The FTIR spectra showed no change in lipids of the MNG and SNG groups compared with the normal group. Moreover, SNG could reduce IL-1β content to a level that was not different from the level in the normal groups. Therefore, the oral application of MNG and SNG could protect against 5-FU-induced small intestinal mucositis in mice. 
     TH, publication_article_keyword Melatonin, Succinyl melatonin, Niosome, 5-Fluorouracil, Small intestinal mucositis 
TH, publication_article_writer
567100018-4 Miss PRANGTIP UTHAIWAT [TH, publication_article_main_writer]
Graduate School Doctoral Degree

TH, publication_article_evaluation มีผู้ประเมินอิสระ 
TH, publication_article_status ได้รับการตอบรับให้ตีพิมพ์ 
TH, publication_article_level นานาชาติ 
TH, publication_article_citation TH, publication_article_citation_false 
TH, publication_article_part_of_thesis TH, publication_article_part_of_thesis_true 
TH, publication_article_part_of_graduate TH, publication_article_part_of_graduate_false 
TH, publication_attachment_file
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