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Publication
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| Title of Article |
Antiproliferative polyketides from fungus Xylaria cf. Longipes SWUF08-81 in different culture media |
| Date of Acceptance |
19 December 2023 |
| Journal |
| Title of Journal |
Natural Products and Bioprospecting |
| Standard |
ISI |
| Institute of Journal |
springer nature |
| ISBN/ISSN |
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| Volume |
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| Issue |
14 |
| Month |
December |
| Year of Publication |
2024 |
| Page |
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| Abstract |
Bioactive compounds from the wood-decay fungus Xylaria cf. longipes SWUF08-81, cultivated in three different culture media (GM, YM and PDB), were isolated. Their structures and stereochemistry were deduced from spectroscopic and MS data analysis, together with quantum chemical calculations of 13C NMR chemical shifts and electronic circular dichroism (ECD) spectra. Five undescribed polyketides including dibenzofuran (1), mellein (2), dihydroisocoumarin (15), and two pyrans (16, 17), together with twenty-three compounds were determined. Compounds 18 and 20 were significantly toxic against cancer cell lines (HCT116, HT29, MCF-7 and HeLa) based on the MTT assay. Quantification by HPLC showed that 18 was produced three-fold higher in the broth of PDB than YM. These studies showed that the production of different compounds were primarily dependent on nutrition sources and it has given a starting point for the growth optimization conditions for the scaling up of bioactive compounds production. |
| Keyword |
Xylaria, Dibenzofuran, Asperentin, Pyran, Antiproliferative activity, HPLC analysis |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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